Increased arterial stiffness correlated with disease activity in systemic lupus erythematosus
Identifieur interne : 001992 ( Main/Exploration ); précédent : 001991; suivant : 001993Increased arterial stiffness correlated with disease activity in systemic lupus erythematosus
Auteurs : Q. Shang [Hong Kong] ; Ls Tam [Hong Kong] ; Ekm Li [Hong Kong] ; Gwk Yip [Hong Kong] ; Cm Yu [Hong Kong]Source :
- Lupus [ 0961-2033 ] ; 2008-12.
English descriptors
- Teeft :
- Active disease, Arterial stiffness, Arthritis rheum, Atherosclerosis, Augmentation, Blood pressure, Brachial, Cardiovascular, Carotid, Carotid thickness, Chinese university, Disease activity, Disease activity index, Early atherosclerosis, Early increase, Erythematosus, Hong kong, Independent risk factor, Lupus, Lupus correlation, Organ damage, Prothrombin time, Pulse wave velocity, Risk factors, Sledai, Slicc, Stiffness, Systemic, Systemic lupus erythematosus, Systolic blood pressure, Traditional risk factors, Wales hospital, White blood cell count.
Abstract
To evaluate the relationships between arterial stiffness, disease activity and end-organ damage in systemic lupus erythematosus (SLE), non-invasive vascular assessments were made on 32 female SLE patients and 32 female normal controls. The patients had significantly increased brachial-ankle pulse wave velocity (PWV) (13.06 ± 1.79 vs. 11.50 ± 1.00 m/s; P < 0.001), heart-ankle PWV (8.98 ± 1.16 vs. 7.88 ± 0.73 m/s; P < 0.001), carotid augmentation index (AI) (21.6 ± 17.2% vs. 5.4 ± 14.0%; P = 0.001) and carotid intima-medial thickness (IMT) (0.753 ± 0.132 vs. 0.644 ± 0.092 mm; P = 0.002) when compared with controls. The disease activity and organ damage were evaluated by SLE disease activity index (SLEDAI) and systemic lupus international collaborating clinics (SLICC) damage index. Patients with active disease (SLEDAI ≥ 3) had significantly higher carotid AI (34.4 ± 9.7% vs. 17.8 ± 17.3%, P < 0.05) than stable ones (SLEDAI < 3) and those with organ damage (SLICC ≥ 1) had significantly higher heart-ankle PWV (9.69 ± 1.13 vs. 8.61 ± 1.02 m/s, P < 0.05) than those with SLICC = 0. After making adjustments for age, body mass index (BMI) and blood pressure, carotid AI was found to show correlation with SLEDAI and haPWV with SLICC. A carotid AI value of 33.3% identified SLEDAI ≥ 3 with a sensitivity of 83% and a specificity of 80%, whereas a heart-ankle PWV value of 9.0 m/s identified SLICC ≥ 1 with a sensitivity of 91% and a specificity of 67%. In conclusion, SLE was an independent risk factor of sub-clinical atherosclerosis and arterial stiffness may identify the presence of active disease.
Url:
DOI: 10.1177/0961203308092160
Affiliations:
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The patients had significantly increased brachial-ankle pulse wave velocity (PWV) (13.06 ± 1.79 vs. 11.50 ± 1.00 m/s; P < 0.001), heart-ankle PWV (8.98 ± 1.16 vs. 7.88 ± 0.73 m/s; P < 0.001), carotid augmentation index (AI) (21.6 ± 17.2% vs. 5.4 ± 14.0%; P = 0.001) and carotid intima-medial thickness (IMT) (0.753 ± 0.132 vs. 0.644 ± 0.092 mm; P = 0.002) when compared with controls. The disease activity and organ damage were evaluated by SLE disease activity index (SLEDAI) and systemic lupus international collaborating clinics (SLICC) damage index. Patients with active disease (SLEDAI ≥ 3) had significantly higher carotid AI (34.4 ± 9.7% vs. 17.8 ± 17.3%, P < 0.05) than stable ones (SLEDAI < 3) and those with organ damage (SLICC ≥ 1) had significantly higher heart-ankle PWV (9.69 ± 1.13 vs. 8.61 ± 1.02 m/s, P < 0.05) than those with SLICC = 0. After making adjustments for age, body mass index (BMI) and blood pressure, carotid AI was found to show correlation with SLEDAI and haPWV with SLICC. A carotid AI value of 33.3% identified SLEDAI ≥ 3 with a sensitivity of 83% and a specificity of 80%, whereas a heart-ankle PWV value of 9.0 m/s identified SLICC ≥ 1 with a sensitivity of 91% and a specificity of 67%. In conclusion, SLE was an independent risk factor of sub-clinical atherosclerosis and arterial stiffness may identify the presence of active disease.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Hong Kong"><noRegion><name sortKey="Shang, Q" sort="Shang, Q" uniqKey="Shang Q" first="Q" last="Shang">Q. Shang</name></noRegion><name sortKey="Li, Ekm" sort="Li, Ekm" uniqKey="Li E" first="Ekm" last="Li">Ekm Li</name><name sortKey="Tam, Ls" sort="Tam, Ls" uniqKey="Tam L" first="Ls" last="Tam">Ls Tam</name><name sortKey="Yip, Gwk" sort="Yip, Gwk" uniqKey="Yip G" first="Gwk" last="Yip">Gwk Yip</name><name sortKey="Yu, Cm" sort="Yu, Cm" uniqKey="Yu C" first="Cm" last="Yu">Cm Yu</name><name sortKey="Yu, Cm" sort="Yu, Cm" uniqKey="Yu C" first="Cm" last="Yu">Cm Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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